Elizabeth Tyrrell, daughter of James Ussher, Anglican Archbishop of Armagh and Primate of All Ireland, and Phoebe Ussher (née Challoner) was born in London in 1619. Around 1653 she married Sir Timothy Tyrrell, of Oakley, Buckinghamshire. They later moved from Oakley to Shotover. They had four sons and eight daughters, the first son being James Tyrrell.
According to the dedication on a memorial to her, she was a person of exemplary worth and piety: an excellent wife and most indulgent mother, and highly charitable to the poor. After being married about forty years, she died in 1693, to the great grief of her husband. She is buried with her husband in Oakley Church.